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2025
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Determination of hexamethylenetetramine content by fully automated potentiometric titration
1. Introduction
Urotropin, with the molecular formula C6H12N4, also known as hexamethylenetetrammonium, has a wide range of applications. In medicine, it is commonly used as a disinfectant and antiseptic, for the prevention and treatment of chronic or recurrent lower urinary tract infections, and for treating hyperhidrosis of the hands and feet and bromhidrosis. In the military, it is commonly used as military fuel. In industry, it is mainly used as a curing agent for resins and plastics, a catalyst and foaming agent for amino plastics, and an accelerator for rubber vulcanization. This method uses the Shanghai Jiahang JH-T6 fully automatic potentiometric titrator to determine the content of the active ingredient in this drug through perchloric acid titration to see if its content meets the requirements for mass production. This method has a simple experimental procedure, is time-efficient, and avoids subjective errors caused by manual endpoint determination, making it a good choice for detecting the content of this type of drug.
2. Instruments and Equipment
2.1 Instruments
JH-T6 fully automatic potentiometric titrator, composite non-aqueous pH electrode.
2.2 Reagents
Perchloric acid standard titration solution (0.1 mol/L), anhydrous methanol.
3 Experimental Methods
3.1 Experimental Procedure
Accurately weigh 0.1 g of the test sample (accurate to 0.0001 g), place it in a titration vessel, add 50 mL of anhydrous methanol, place the vessel on a titration stand, and turn on the stirrer to completely dissolve the sample. Titrate with the standardized 0.1 mol/L perchloric acid titrant until the potential breakthrough endpoint is reached, and record the volume consumed.
3.2 Parameter Settings
4. Results and Discussion
4.1 Experimental Results
Calculation formula:
Calculation formula:
4.2 Atlas
4.3 Conclusion
The determination of hexamethylenetetramine content using the JH-T6 fully automatic potentiometric titrator showed good repeatability, with all results falling within the standard range and RSD ≤ 0.5%. The T960 fully automatic potentiometric titrator fully meets the requirements for this sample determination.
References:
[1] 2020 Pharmacopoeia of the People's Republic of China [M]. Part II. Beijing: China Medical Science and Technology Press.
Keyword:
automated potentiometric titration
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